产品货号：
GS4396
中文名称：
重组人CNTF
英文名称：
Recombinant Human Ciliary Neurotrophic Factor
产品规格：
5μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 22.9kDa,a single non-glycosylated polypeptide chain containing 200 amino acids.
储存条件：冷冻（-20℃）
概述
Ciliary neurotrophic factor(CNTF)is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations.It was initially identified as a trophic factor for embryonic chick ciliary parasympathetic neurons in culture.The protein is also a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks.In addition,CNTF is useful for treatment of motor neuron disease and it could reduce food intake without causing hunger or stress.CNTF is structurally related to IL-6,IL-11,LIF and OSM.All of these four helix bundle cytokines share gp130 as a signal-transducing subunit in their receptor complexes.Recombinant human CNTF containing 200 amino acids and it shares 82%and 83%a.a.sequence identity with mouse and rat CNTF.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人CNTF，CNTF, Human，Recombinant Human Ciliary Neurotrophic Factor
储存条件：冷冻（-20℃）
概述
Ciliary neurotrophic factor(CNTF)is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations.It was initially identified as a trophic factor for embryonic chick ciliary parasympathetic neurons in culture.The protein is also a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks.In addition,CNTF is useful for treatment of motor neuron disease and it could reduce food intake without causing hunger or stress.CNTF is structurally related to IL-6,IL-11,LIF and OSM.All of these four helix bundle cytokines share gp130 as a signal-transducing subunit in their receptor complexes.Recombinant human CNTF containing 200 amino acids and it shares 82%and 83%a.a.sequence identity with mouse and rat CNTF.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞97%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 150ng/ml,corresponding to a specific activity of>6.7×103 IU/mg. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4. |
| 内毒素 | Less than 1 EU/μg of rHuCNTF as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | MAFTEHSPLT PHRRDLCSRS IWLARKIRSD LTALTESYVK HQGLNKNINL DSADGMPVAS TDQWSELTEA ERLQENLQAY RTFHVLLARL LEDQQVHFTP TEGDFHQAIH TLLLQVAAFA YQIEELMILL EYKIPRNEAD GMPINVGDGG LFEKKLWGLK VLQELSQWTV RSIHDLRFIS SHQTGIPARG SHYIANNKKM |
相关搜索：重组人CNTF，CNTF, Human，Recombinant Human Ciliary Neurotrophic Factor